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David E Sleat Selected Research

Tripeptidyl-Peptidase 1

1/2020Lysosomal protein thermal stability does not correlate with cellular half-life: global observations and a case study of tripeptidyl-peptidase 1.
1/2018Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis.
3/2017Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease.
1/2017A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism.
3/2014Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain.
1/2012Systemic administration of tripeptidyl peptidase I in a mouse model of late infantile neuronal ceroid lipofuscinosis: effect of glycan modification.
5/2010Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.
3/2009Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice.
10/2008Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
6/2008Residual levels of tripeptidyl-peptidase I activity dramatically ameliorate disease in late-infantile neuronal ceroid lipofuscinosis.
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David E Sleat Research Topics

Disease

18Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
01/2020 - 10/2004
9Neurodegenerative Diseases (Neurodegenerative Disease)
01/2018 - 04/2004
7Lysosomal Storage Diseases (Lysosomal Storage Disease)
11/2017 - 04/2006
2Disease Progression
11/2019 - 12/2012
2Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
01/2014 - 11/2007
2Inborn Genetic Diseases (Disease, Hereditary)
01/2012 - 03/2007
2Neoplasms (Cancer)
04/2009 - 03/2007
2Alzheimer Disease (Alzheimer's Disease)
04/2009 - 03/2007
1Neuroinflammatory Diseases
11/2019
1Neuroblastoma
10/2008
1Nervous System Heredodegenerative Disorders
06/2008
1Arthritis (Polyarthritis)
03/2007
1Lipidoses
11/2006

Drug/Important Bio-Agent (IBA)

14Tripeptidyl-Peptidase 1IBA
01/2020 - 10/2004
9Peptide Hydrolases (Proteases)FDA Link
01/2020 - 04/2008
9Proteins (Proteins, Gene)FDA Link
11/2019 - 03/2007
6lysosomal proteinsIBA
12/2012 - 11/2006
4EnzymesIBA
03/2017 - 04/2008
3Biomarkers (Surrogate Marker)IBA
11/2019 - 10/2006
2Phenobarbital (Luminal)FDA Link
01/2014 - 11/2006
2Glycoproteins (Glycoprotein)IBA
10/2008 - 10/2006
2CholesterolIBA
11/2007 - 04/2004
1ProteomeIBA
11/2019
1Lysergic Acid Diethylamide (LSD)IBA
03/2014
1Peptides (Polypeptides)IBA
03/2014
1Mannose (D-Mannose)IBA
12/2012
1Polysaccharides (Glycans)IBA
01/2012
1Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA
10/2011
1mitochondrial ATPase subunit cIBA
05/2010
1Glial Fibrillary Acidic ProteinIBA
05/2010
1N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA
07/2009
1Cathepsin CIBA
10/2008
1HydrolasesIBA
03/2007
1Biological ProductsIBA
04/2006
1Serine Proteases (Serine Protease)IBA
10/2004
1LipidsIBA
04/2004

Therapy/Procedure

2Therapeutics
01/2017 - 03/2014
1Enzyme Replacement Therapy
04/2008